Oddly enough, the rats given the 100 mg dosage showed the opposite behavior. In two animal-based studies, Bulbine Natalensis was shown to significantly increase testosterone levels. There are few herbs that actually boost testosterone, fewer that really lower estrogen, but none that do both exceptionally well – except Bulbine Natalensis.. Want to know what supplements been proven in scientific case studies to increase testosterone in humans? Questions about your PRWeb account or interested in learning more about our news services? Since my first post (ver. Sixty male rats were grouped into four (A-D) consisting of 15 each. These findings have since been reproduced in unpublished human studies, and today ProLensis™ features in some of the most popular testosterone-boosting dietary supplements available. The main motive for this project is to organize and put an end to the scatteredness of nootropics-literature and the lack of a single place with only human studies. In two animal-based studies, Bulbine Natalensis was shown to significantly increase testosterone levels. In the only human study with Bulbine natalensis, it was consumed at a dosage of 325 mg twice a day . With that said, the effect from Bulbine Natalensis was so dramatic that researchers concluded Bulbine Natalensis may promote liver side effects that are comparable to a steroid cycle. At the conclusion of the trial, ProLensis™ was found to be as safe as a maltodextrin placebo. Bulbine Natalensis is a good natural testosterone booster, which greatly influence testosterone level and thus, increase drive and performance. There are very few human studies of the effects of bulbine natalensis, since it is a relatively new health product. © iTestosterone 2017 - All Rights Reserved -, iTestosterone – Men's Nutrition, Fitness, Health & Testosterone, Best Supplements for CrossFit – Boost Endurance & Strength, How to Build Bigger Biceps: 5 Tricks for Huge Arms, 5 Health Benefits of Creatine for Athletes – Strength, Performance, Nitrosigine Pre-Workout Nitric Oxide Booster, The 4 Best Crossfit Pre-Workout Supplements Reviewed, Top 3 Best Multivitamins for Athletes & Bodybuilders Ranked. While this was not the cause of death for the animals, it is of concern because organ shrinkage can lead to organ failure. It has long been used in traditional medicines as an aphrodisiac, and is currently being studied with experts looking at its testosterone boosting affects. The findings were presented at the recent International Society of Sports Nutrition (ISSN) conference held in Clearwater beach, Florida in June 2012. Bulbine natalensis is a herb that grows in the southern parts of Africa where it has traditionally been used as an aphrodisiac. 1.0) 4 weeks ago I have been fixing and dealing with the issues and constructive criticism the project received on the first post. At the conclusion of the trial, ProLensis™ was found to be as safe as a maltodextrin placebo. ©Copyright 1997-2015, Vocus PRW Holdings, LLC. The human safety study, performed by The Center for Applied Health Sciences (CAHS) in Stow, Ohio, was a placebo-controlled, double-blind twenty-eight day trial involving thirty-six healthy adults. Bulbine natalensis is a plant indigenous to Africa, traditionally used as an aphrodisiac and tonic in tribesmen. Today, it is touted as a potent testosterone booster.. Bulbine natalensis has been shown to increase testosterone levels in rats, but there is currently no research demonstrating this effect in humans. Sports Nutrition Research has also announced that there are plans for The Center for Applied Health Science to conduct more human trials involving ProLensis™ in the future. The incisional wounds were used to test tensile strength of the healed wounds using a tensiometer.In the in vitro studies, neither extract caused cytotoxicity to either the fibroblast or keratinocyte cells. As the first step in a series of experiments designed to assess in the in vivo effects of Bulbine natalensis (ProLensis™) supplementation, we performed a placebo-controlled, double-blind clinical trial to assess the short-term safety of this ingredient. It has also been shown to exhibit potent aphrodisiac qualities. Check out our article on the 7 best natural testosterone boosters. Falling testosterone levels are something all men have to face as they age. The African continent has a rich history of medicinal plant use, and a large number of … The dosing seems, in rats, to have a inverse U relationship to testosterone, a sem linear downwards relationship to estrogen. Although no human research can be found for the herb’s benefits, animal studies are promising: Bulbine (25 and 50 mg/kg body weight) enhances sexual behavior with effects similar to Viagrain rats This study fed 75 healthy male rats different amounts of bulbine natalensis along with a group of placebo and com… Looking through user reviews, you’ll find that the only common negative complaint is that certain brands didn’t work; there are no reports of any horror-story side effects. Editor’s Note: While the potential increase in DHT does not concern me, as noted several times throughout other articles on iTestosterone; I prefer to focus heavily on supplements proven in human based case studies. July 14, 2012. However, the catalytic activity of CYP2C9 was also … In the rat studies, an extract 10:1 was used, where 50 mg/kg where the dose with the highest testosterone level measured. Native to South Africa, Bulbine Natalensis has long been used in traditional medicine as a way to improve libido and sexual performance in men. Ethnopharmacological relevance. Stefan Gafner, PhD, ABC’s chief science officer, said: “We are grateful to Afrigetics Botanicals for its adoption of Bulbine natalensis. Bulbine Natalensis Recommended Dosage, Benefits, & Side Effects In the fitness community, users typically consume Bulbine Natalensis with the goal of increasing testosterone and sex drive. The photo shows the African botanical Bulbine natalensis. Bulbine natalensis is quickly gaining popularity in the sports supplement world. In 2009 researchers at the University of Ford Hare in South Africa published the results of an animal study in which they had given male rats water-based extracts of Bulbine natalensis for a week. Human studies are needed, however. It has great influence on cognition and sexuality, and currently it is used as a testosterone booster. After 30, a man can expect to lose 1% of his testosterone a year, year on year. Those rats given 100 mg per kilogram of bodyweight did not see the same results. Aqueous extract of Bulbine natalensis Baker (Asphodelaceae) stem at 25, 50 and 100 mg/kg body weight was investigated for anabolic and androgenic effects in male Wistar rats. This testosterone booster has only recently come to light in Western fitness circles, but demonstrates very positive results so far.. What’s more, as mentioned above, one study confirmed the safety of it for the same period of a supplement cycle: four weeks. Bulbine Natalensis. In other words, the rats’ libido increased significantly. The gel from the leaves of Bulbine natalensis (BN) and Bulbine frutescens (BF) is commonly used as a traditional medicine in South Africa for the treatment of skin wounds and burns. Another study mirrored these benefits, confirming the superiority of the 25 mg to 50 mg per kilogram of bodyweight dosage. The question is: Based on research, it is potentially a very dangerous supplement. Cell proliferation was greater than 100% at 0.1-5 and 100-300 μg/ml for Bulbine natalensis and at 0.1μg/ml for Bulbine frutescens. My recommendation is that if you’re going to use Bulbine Natalensis, be sure to cycle on and off (four weeks on, four weeks off) as you would any fitness supplement. These studies further suggest that compared to other herbal extracts used for boosting testosterone, Bulbine Natalensis could be the only one with the ability to lower estrogen levels. Studies have shown that it increases circulating testosterone significantly with dosage of 50 mg/kg bodyweight. Questions about a news article you've read? For more information about ProLensis™ or to order ProLensis™ for your own product line please visit http://www.ProLensis.com or contact info(at)ProLensis(dot)com. Bulbine natalensis is a medicinal herb, selling as natural testosterone booster and widely used for enhancing the male sexual performance.. B. natalensis extracts and its constituents activated PXR and induced mRNA expression of cytochrome P450 genes resulting into an increased activity of CYP3A4 and CYP2C9 enzymes in hepatic cells.. In one study, 25 mg to 50 mg per kilogram of bodyweight of Bulbine Natalensis was shown to increase testosterone levels as well as serum follicle stimulating and luteinizing hormone concentrations. While human-based studies are pending, it has been shown to be safe for human consumption within a 28-day period. Stefan Gafner, PhD, ABC’s chief science officer, said: “We are grateful to Afrigetics Botanicals for its adoption of Bulbine natalensis. 900mg for a 250lb person. Bulbine Natalensis is a South African shrub that has been used in traditional medicine to treat a variety of conditions including diabetes and convulsions. It’s easy to see why – the effects of extracts of Bulbine natalensis recorded in animal studies are amazing. The results of the study are to be published in the highly esteemed scientific Journal of the International Society of Sports Nutrition (JISSN). In rat studies, a cycle of bulbine natalensis has effects on the kidney and liver that are similar to that of a methylated testosterone pill.study On the other hand, the only human study ever conducted on bulbine natalensis concluded that short term use seems to be safe.study Let’s take a look at what PubMed has to say about the potential side effects of bulbine natalensis. Hair Loss: Since Bulbine Natalensis increases testosterone and cholesterol levels, precursors for dihydrotestosterone (DHT) conversion, you do have the risk of hair loss. Bulbine natalensis is a plant indigenous to Africa, traditionally used as an aphrodisiac and tonic in tribesmen. Bulbine Natalensis is also known as Ibhucu, Rooiwortel and Ingcelwane. David Sautter is a NASM-certified personal trainer, NASM-certified fitness nutrition specialist, ACE-certified sports conditioning specialist, and health and fitness writer featured in Cellucor and Workout Labs. Increases Libido and Sexual Performance: In the same study from above, researchers found that rats given the 25 mg to 50 mg per kilogram of bodyweight dosage engaged in more frequent sexual behavior. Bulbine Natalensis and the Importance of Natural Testosterone Production. Bulbine Natalensis is an herb known for its aphrodisiac qualities. The very word testosterone produces an image of an “Alpha male” Blood, sweat and cold iron. ProLensis™ is a well-studied specific extract of bulbine natalensis, with several animal model studies demonstrating the benefit for controlling the hormones testosterone and estrogen – both hormones involved in body augmentation. Indigenous to South Africa. Group A (control) was orally treated with 0.5 mL of disti … It works more than twice as well as Fadogia, at half the dose. Sports Nutrition Research is a raw materials provider and supplement formulation team that consults for several dietary supplement manufacturers. The values investigated by the researchers were clinical labs including renal, hepatic and haematological biomarkers. Bulbine Natalensis Recommended Dosage, Benefits, and Side Effects. In one study, 25 mg to 50 mg per kilogram of bodyweight of Bulbine Natalensis was shown to increase testosterone levels as well as serum … When he’s not in the gym or on the road, he enjoys reading and salsa dancing. Again, this isn’t something that’s been confirmed in a human-based study but it’s something to keep in mind, especially if you have liver or kidney issues. The photo shows Bulbine natalensis.Its Zulu name is ibhucu; Afrikaners call it rooiwortel.Herbalists sometimes prescribe the root of the plant for men with impotence problems. Yeah I also read, that in rats, to high a dose of Bulbine Natalensis could have the opposite effect. Vocus, PRWeb, and Publicity Wire are trademarks or registered trademarks of Vocus, Inc. or Vocus PRW Holdings, LLC. ProLensis™ is a well-studied specific extract of bulbine natalensis, with several animal model studies demonstrating the benefit for controlling the hormones testosterone and estrogen – both hormones involved in body augmentation. you will end up with a total of 347% of your original level). In my personal opinion, there is no reason to believe a nutrient will provide any specific value to the human body until a human based case study gives reason to be optimistic. Rat studies investigating how bulbine natalensis interacts with testosterone note that 50mg/kg (of a 10:1 extraction) appear to be the optimal dosage, and based on Body Surface Area Conversions, this correlates into an estimated human dose of 8mg/kg or:. In addition, a clinical study involving one human male showed this substance increased both his testosterone levels by 35%. It’s essential to note that except for one all studies analyzing the impacts of Bulbine Natalensis have been performed on rats instead of people. Bulbine Natalensis is a natural herb that originates from the South and South Eastern parts of Africa. While I agree with the overall assessment in this article, as I always say, what works in rats usually does not end up working in humans. For decades in the strength, bodybuilding and sporting world athletes have searched for optimal testosterone production in order to improve performance, add muscle mass, improve recovery or, even aid sexual performance. Despite the herb’s documented benefits and uses in traditional medicine, current studies on B. natalensis are scant. Human studies are needed, however. While Fadogia has been shown in rodent studies to increase testosterone by 100% (doubling your natural test levels! Journal of the International Society of Sports Nutrition (JISSN). The optimal dosage for testosterone effects was found to be 50 mg/kg in rat studies. Also monitored were physical parameters, including heart rate, blood pressure and EKG. The aqueous extract of Bulbine natalensis stem at these doses (25 and 50 mg/kg body weight) may be used in the management of disorders of desire/libido, premature ejaculation and erectile dysfunction in males. 730mg for a 200lb person. Despite the absence of human-based studies and trials (for now), I think Bulbine Natalensis could be of use to guys who want to increase their levels of testosterone and libido. ), Bulbine Natalensis clocks in at 247% (i.e. While it is far more anabolic and androgenic than testosterone, DHT is thought to be one of the primary reasons for male pattern baldness and hair loss. The Dangers of Bulbine Natalensis. Its long-term effects are unknown, but a clinical study of its use in men for a period of 28 days stated that the supplement is safe according to various markers of health, including blood, kidney, liver and heart markers. Clusters of star-shaped yellow flowers on long thin … In the wellness group, clients regularly devour Bulbine Natalensis with the objective of expanding testosterone and sex drive. Treatment with both leaf gel extracts has previously been demonstrated to increase tensile strength and protein and DNA content in pig dermal wounds. A dosage of 50 mg/kg was established as optimal in rat studies. Let’s take a look at what science is saying about this compound, the benefits of it, and whether you should use it to boost testosterone and sex drive. HydroMax or GlycerSize – What Is It & Which Is Better. There is evidence from the limited studies undertaken on Bulbine Natalensis to suggest that there is a toxic effect, specifically relating to the liver. It is these plant-based compounds that give Bulbine Natalensis its medicinal properties. And all of this is achieved at a dose of 50mgs/kg (rat dose), which translates very well to a low human dose, which … He has over 12 years of experience in the fitness industry and he has been the driving creative force behind numerous e-books and training guides on muscle building, weight loss, and performance enhancement. The Bulbine Natalensis supplement is the isolated stem of the plant and the compounds within such as tannins (polyphenols), saponins (antioxidants), and alkaloids (nitrogen and carbon molecules). These doses are currently only estimates, but … David is an avid traveler and loves to hike. The results are indicative of prosexual stimulatory potentials of Bulbine natalensis in male rats. Reach out to the author: contact and available social following information is listed in the top-right of all news releases. Bulbine natalensis is a perennial herb indigenous to South Africa that is currently being marketed as a prosexual product for men. Animal studies show that it may increase testosterone, but only at specific doses - too high doses can have a negative impact on long-term health. What was once tribal knowledge is now getting international attention as studies are revealing the benefits of Bulbine Natalensis. As yet, the limited number of human studies undertaken have either failed to reproduce these results or shown no impact on testosterone levels at all. 550mg for a 150lb person. The prosexual effect of the testosterone booster ProLensis™ (Bulbine natalensis) by John Connor. The rodent data suggests a testosterone boost of 347% compared to baseline, while lowering estrogen by 35%. This is an important finding for ProLensis™ as it provides the first peer-reviewed documentation of safety in humans. Unlike hyped supplements such as tribulus (that don't increase testosterone) the South African herb Bulbine Natalensis works and has been shown in studies to increase testosterone by a whopping 347% and crush estrogen by 35%. Potential Organ Risk: One study involving rats found that although Bulbine Natalensis did boost testosterone and libido, it also shrunk the liver and kidneys. The African continent has a rich history of medicinal plant use, and a large number of these plants are … Bulbine Natalensis is a type of herb from South Eastern and Southern African countries and has been used for years as a form of aphrodisiac and other health benefits. The cornerstone ingredient of Aggressive Strength is the one and only Bulbine Natalensis. ... given the significance of the results in all of the studies undertaken so far, there is a strong probability that the effects can be seen in human equivalent doses. ProLensis: A Phytochemical For Body Recomposition Through Testosterone Augmentation, New York, New York (PRWEB) In fact, there has only been one human study to date, and it only looked at the short-term use of B. natalensis supplementation to no significant results. An extract 10:1 was used, where 50 mg/kg where the dose testosterone, a sem linear downwards relationship testosterone... Medicine, current studies on B. 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